Fruit Extract Facilitates Anti-Adipogenic Activity of Extract in 3T3-L1 Adipocytes by Reducing Oxidative Stress.

Obesity is a metabolic disorder associated with chronic oxidative stress and inflammation. Recruitment of inflammatory cells to adipose tissue and subsequent production of a large amount of reactive oxygen species (ROS) facilitates adipocyte differentiation and promotes lipid accumulation. The removal of ROS with anti-oxidants appeared an effective strategy against lipid accumulation. Here, we chose , a good dietary source of anti-oxidants and tested the anti-adipogenic potential of extract (CE). CE effectively suppressed the ROS production and lipid accumulation in H₂O₂-stimulated 3T3-L1 cells. CE also inhibited the expression of CEBP- and PPAR-, the transcription regulators of adipocyte differentiation. These data suggest that CE might suppress the adipocyte differentiation through ROS scavenging action. Also, CE and extract (GE) appeared act additively in reducing ROS and in inhibiting lipid accumulation. It implied a potential usefulness of this combination in the management of obesity related disorders.