We report on the gas-sensing characteristics of a van der Waals heterojunction consisting of graphene and a MoS flake. To extract the response actually originating from the heterojunction area, the other gas-sensitive parts were passivated by gas barrier layers. The graphene/MoS heterojunction device demonstrated a significant change in resistance, by a factor of greater than 10, upon exposure to 1 ppm NO under a reverse-bias condition, which was revealed to be a direct reflection of the modulation of the Schottky barrier height at the graphene/MoS interface. The magnitude of the response demonstrated strong dependences on the bias and back-gate voltages. The response further increased with increasing reverse bias. Conversely, it dramatically decreased when measured at a large forward bias or a large positive back-gate voltage. These behaviors were analyzed using a metal-semiconductor-metal diode model consisting of graphene/MoS and counter Ti/MoS Schottky diodes.
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http://dx.doi.org/10.1021/acsami.8b14667 | DOI Listing |
Background: Neurodevelopmental origins of functional variation through the lifespan are acknowledged, but pathways need to be identified. The objectives of the project Set-to-change is to test whether and how early life environmental factors and genetic makeup regulate brain and cognition and its change, as well as neurocognitive plasticity in response to training through the lifespan.
Method: Preliminary analyses for the first months are presented.
Alzheimers Dement
December 2024
USC Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Background: Alzheimer's disease (AD) is associated with complex pathophysiology including synaptic dysregulation, compromised neurotrophic signaling, deficits in autophagic flux and neuroinflammation). Skeletal muscle regulates many brain functions relevant to aging, by activating the muscle-to-brain axis through the secretion of skeletal muscle originating factors (myokines) with cellular-modifying, neuro and geroprotective properties. Our group developed transgenic mice that overexpress the skeletal muscle human Transcription Factor EB (TFEB), a master regulator of lysosomal-to-nucleus signaling, resulting in enhanced proteostasis and neuroprotection in a Tau mouse model.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Massachusetts General Hospital, Boston, MA, USA.
The Congressionally Directed Medical Research Programs (CDMRP) originated in 1992 via a Congressional appropriation to foster novel approaches to biomedical research in response to the expressed needs of its stakeholders-the American public, the military, and Congress. Currently there are 35 CDMRP programs each addressing a specific disease or condition. The Peer Reviewed Alzheimer's Research Program (PRARP) began in 2011 and has a vision to mitigate the impact of Alzheimer's and related dementias associated with military and diverse risks.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, 646000 Luzhou, China.
Aging is a complex biological process that involves the gradual decline of cellular, tissue, and organ functions. In kidney, aging manifests as tubular atrophy, glomerulosclerosis, and progressive renal function decline. The critical role of senescence-associated macrophage in diseases, particularly kidney diseases, is increasingly recognized.
View Article and Find Full Text PDFCan Vet J
January 2025
Department of Population Medicine (Belanger, Spence, Clow) and Department of Pathobiology (Weese), Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1; Ontario Ministry of Agriculture, Food and Agribusiness, 1 Stone Road West, Guelph, Ontario N1G 4Y2 (Anderson).
Background: As numbers of dogs entering Canada from abroad are increasing, it is essential to understand the scope, challenges, and risks associated with canine importation. Canadian veterinarians' collective experience with and clinical knowledge of imported dogs can provide valuable insights into this practice.
Objective: To describe Canadian veterinarians' experiences with, and perspectives of, imported dogs in clinical practice.
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