AI Article Synopsis
- P-glycoprotein (P-gp) is a protein commonly overexpressed in cancer cells that contributes to their resistance to multiple chemotherapy drugs.
- A mathematical model was developed to analyze both direct protein transfer between cells and indirect transfer from cells to the surrounding liquid.
- The study found that including the indirect transfer in simulations improved the alignment of mathematical predictions with experimental results, highlighting its impact, which is often overlooked in experiments.
Article Abstract
The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results.
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| http://dx.doi.org/10.1016/j.jtbi.2018.10.040 | DOI Listing |
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