AI Article Synopsis
- Osteogenesis imperfecta (OI) affects dental and craniofacial development, potentially impacting oral health-related quality of life (OHRQoL) in children and adolescents, although research on this topic is limited.
- A study involving 138 participants aged 8-14 assessed OHRQoL using the Child Perceptions Questionnaire, finding no significant differences among OI types for younger children, but notable differences for older adolescents (11-14 years) based on OI severity.
- The findings suggest that the severity of OI significantly affects OHRQoL in adolescents aged 11-14, particularly in terms of functional limitations, while younger children (8-10) were less impacted.
Article Abstract
Background: Osteogenesis imperfecta (OI) affects dental and craniofacial development and may therefore impair Oral Health-Related Quality of Life (OHRQoL). However, little is known about OHRQoL in children and adolescents with OI. The aim of this study was to explore the influence of OI severity on oral health-related quality of life in children and adolescents.
Methods: Children and adolescents aged 8-14 years were recruited in the context of a multicenter longitudinal study (Brittle Bone Disease Consortium) that enrolls individuals with OI in 10 centers across North America. OHRQoL was assessed using the Child Perceptions Questionnaire (CPQ) versions for 8 to 10-year-olds (CPQ) and for 11 to 14-year-olds (CPQ).
Results: A total of 138 children and adolescents (62% girls) diagnosed with OI types I, III, IV, V and VI (n = 65, 30, 37, 4 and 2, respectively) participated in the study. CPQ scores were similar between OI types in children aged 8 to 10 years. In the 11 to 14-year-old group, CPQ-scores were significantly higher (i.e. worse) for OI types III (24.7 [SD 12.5]) and IV (23.1 [SD 14.8]) than for OI type I (16.5 [SD 12.8]) (P < 0.05). The difference between OI types was due to the association between OI types and the functional limitations domain, as OI types III and IV were associated with significantly higher grade of functional limitations compared to OI type I.
Conclusion: The severity of OI impacts OHRQoL in adolescents aged 11 to 14 years, but not in children age 8 to 10 years.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202869 | PMC |
| http://dx.doi.org/10.1186/s13023-018-0935-y | DOI Listing |
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