[Study on Degradation of Oxidized Regenerated Cellulose Absorbable Hemostatic Products].

Zhongguo Yi Liao Qi Xie Za Zhi

Biologics and Biomaterials Laboratory, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014.

Published: September 2018

Objective: To study the degradation of oxidized regenerated cellulose absorbable hemostatic products.

Methods: The morphology of the oxidized regenerated cellulose hemostatic products before and after degradation was observed by FTIR and SEM. The degradation products were determined by GPC and HILIC-ELSD.

Results: In the initial stage of degradation, there was a great change in morphology. GPC determined its degradation end point was 10 d; it was determined that its degradation products contained glucose (0.13%) and cellobiose (0.17%) and other components.

Conclusions: A method was established for determining the end point of degradation of oxidized regenerated cellulose, which provided a new idea and reference for the study of the degradation end point.

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Source
http://dx.doi.org/10.3969/j.issn.1671-7104.2018.05.020DOI Listing

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