Human intelligence relies on the vast number of neurons and their interconnections that form a parallel computing engine. If we tend to design a brain-like machine, we will have no choice but to employ many spiking neurons, each one has a large number of synapses. Such a neuronal network is not only compute-intensive but also memory-intensive. The performance and the configurability of the modern FPGAs make them suitable hardware solutions to deal with these challenges. This paper presents a scalable architecture to simulate a randomly connected network of Hodgkin-Huxley neurons. To demonstrate that our architecture eliminates the need to use a high-end device, we employ the XC7A200T, a member of the mid-range Xilinx Artix®-7 family, as our target device. A set of techniques are proposed to reduce the memory usage and computational requirements. Here we introduce a multi-core architecture in which each core can update the states of a group of neurons stored in its corresponding memory bank. The proposed system uses a novel method to generate the connectivity vectors on the fly instead of storing them in a huge memory. This technique is based on a cyclic permutation of a single prestored connectivity vector per core. Moreover, to reduce both the resource usage and the computational latency even more, a novel approximate two-level counter is introduced to count the number of the spikes at the synapse for the sparse network. The first level is a low cost saturated counter implemented on FPGA lookup tables that reduces the number of inputs to the second level exact adder tree. It, therefore, results in much lower hardware cost for the counter circuit. These techniques along with pipelining make it possible to have a high-performance, scalable architecture, which could be configured for either a real-time simulation of up to 5120 neurons or a large-scale simulation of up to 65536 neurons in an appropriate execution time on a cost-optimized FPGA.
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http://dx.doi.org/10.3389/fnins.2018.00698 | DOI Listing |
Arch Phys Med Rehabil
January 2025
Department of Physical Medicine and Rehabilitation, School of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Objectives: To evaluate the combined effect of two different regenerative therapies, extracorporeal shock wave therapy (ESWT) and platelet-rich plasma (PRP), along with therapeutic exercise, in patients with lateral epicondylitis (LE).
Design: Prospective, Randomized, Sham-Controlled Trial.
Settings: Outpatient clinic.
Clin Oral Investig
January 2025
Department of Conservative Dentistry and Bucofacial Prostheses, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain.
Objectives: This study aimed to assess the vertical misfit at the implant-abutment interface in external and internal connections across various implant brands, comparing original milled titanium abutments with laser-sintered cobalt-chromium (Co-Cr) abutments.
Materials And Methods: A total of 160 implants from four different brands were utilized, with 80 featuring external connections (EC) and 80 internal connections (IC). Original milled titanium abutments (n = 160) and Co-Cr laser-sintered abutments (n = 160) were randomly attached to each connection type, following the manufacturer's recommended torque.
Mil Med
January 2025
VA Connecticut Healthcare System, West Haven, CT 06516, USA.
Background: Department of Veterans Affairs disability benefits for post-traumatic stress disorder (PTSD), also known as "service connection," have been shown to reduce homelessness and poverty, increase mental health engagement, and improve clinical outcomes. However, gender and race disparities in PTSD service connection have been described in Vietnam and post-Vietnam era Veterans.
Methods: Post-traumatic stress disorder service connection outcomes were assessed in a nationally representative, randomly selected, gender-stratified, prospective panel of 960 Veterans who served during Operations Enduring Freedom, Iraqi Freedom, and New Dawn.
Front Psychiatry
January 2025
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Background: This study aims to evaluate the intervention effect of intermittent Theta burst stimulation (iTBS) on bilateral dorsomedial prefrontal cortex (DMPFC) for negative symptoms in schizophrenia using functional near-infrared spectroscopy (fNIRS) to confirm the therapeutic significance of DMPFC in treating negative symptoms and provide new evidence for schizophrenia treatment and research.
Method: Thirty-nine schizophrenia patients with negative symptoms and mild cognitive impairment were randomly divided into a treatment group (n=20) and a control group (n=19). The treatment group received iTBS in bilateral DMPFC.
Drug Des Devel Ther
January 2025
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Purpose: To explore the postoperative opioid-sparing effect and incidence of adverse events of different dosages of intraoperative esketamine administration in patients undergoing laparoscopic gynecological surgery.
Patients And Methods: Patients undergoing elective gynecological laparoscopic operation was enrolled and randomly allocated to lower-dose esketamine group, higher-dose esketamine group, or control group. Patients in the two intervention groups received esketamine doses of 0.
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