AI Article Synopsis
- Age-related changes in the immune system lead to a weaker response to new pathogens and vaccines, particularly impacting older individuals.
- In a study comparing young adults (ages 19-26) to middle-aged adults (ages 45-58) who were vaccinated with the yellow fever vaccine, distinct differences in antibody responses were observed.
- Younger individuals exhibited a more diverse and efficient antibody repertoire and somatic hypermutation process, indicating a stronger immune response to new pathogens compared to their older counterparts.
Article Abstract
Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In present study we employed 5'RACE UMI-based full length and nearly error-free immunoglobulin profiling to compare plasma cell antibody repertoires in young (19-26 years) and middle-age (45-58 years) individuals vaccinated with a live yellow fever vaccine, modeling a newly encountered pathogen. Our analysis has revealed age-related differences in the responding antibody repertoire ranging from distinct IGH CDR3 repertoire properties to differences in somatic hypermutation intensity and efficiency and antibody lineage tree structure. Overall, our findings suggest that younger individuals respond with a more diverse antibody repertoire and employ a more efficient somatic hypermutation process than elder individuals in response to a newly encountered pathogen.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189279 | PMC |
| http://dx.doi.org/10.3389/fimmu.2018.02309 | DOI Listing |
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