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Biomarker-Guided Dietary Supplementation: A Narrative Review of Precision in Personalized Nutrition.
Nutrients
November 2024
Scientific Research Laboratory, Triangel Scientific, San Francisco, CA 94101, USA.
Dietary supplements (DS) are widely used to address nutritional deficiencies and promote health, yet their indiscriminate use often leads to reduced efficacy, adverse effects, and safety concerns. Biomarker-driven approaches have emerged as a promising strategy to optimize DS prescriptions, ensuring precision and reducing risks associated with generic recommendations. This narrative review synthesizes findings from key studies on biomarker-guided dietary supplementation and the integration of artificial intelligence (AI) in biomarker analysis.
View Article and Find Full Text PDFComprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.
NPJ Precis Oncol
August 2024
Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of biomarker-guided therapy for adult patients with primary brain cancers in the real-world setting within the molecular tumor board Freiburg, Germany. We analyzed genetic profiles, personalized treatment recommendations, and clinical outcomes of 102 patients with 21 brain tumor types.
View Article and Find Full Text PDFRapid multiplex immunohistochemistry for characterizing tumor-immune microenvironment.
Heliyon
July 2024
Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Article Synopsis
- Intratumoral immune profiles play a crucial role in determining prognosis and treatment effectiveness, potentially leading to personalized treatments using specific biomarkers.
- A new 6-marker rapid multiplex immunohistochemistry (IHC) method was created, streamlining the process originally based on a 14-marker system, making it faster and less complex.
- Validation studies demonstrated that this new method reliably assessed immune features and densities in cancer tissues, which could improve the way we understand and treat tumors clinically.
Personalized Medicine in Pancreatic Cancer: The Promise of Biomarkers and Molecular Targeting with Dr. Michael J. Pishvaian.
Cancers (Basel)
June 2024
Icahn School of Medicine at Mount Sinai South Nassau, Oceanside, NY 11572, USA.
Pancreatic cancer, with its alarming rising incidence, is predicted to become the second deadliest type of solid tumor by 2040, highlighting the urgent need for improved diagnostic and treatment strategies. Despite medical advancements, the five-year survival rate for pancreatic cancer remains about 14%, dropping further when metastasized. This review explores the promise of biomarkers for early detection, personalized treatment, and disease monitoring.
View Article and Find Full Text PDFBiomarkers of acute kidney injury: From discovery to the future of clinical practice.
J Clin Anesth
August 2024
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Universitätsklinikum Münster, Germany; Outcomes Research Consortium, Cleveland, OH, USA. Electronic address:
Purpose of this review Acute kidney injury (AKI) is a complex syndrome whose development is associated with an increased morbidity and mortality. Recent studies show that this syndrome is a common complication in critically ill and surgical patients the trajectory of which may differ. As AKI can be induced by different triggers, it is complex and therefore challenging to manage patients with AKI.
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