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An Educational Intervention to Promote Central Nervous System-Active Deprescribing in Dementia: A Pilot Study.
Drugs Aging
January 2025
Center for Clinical Management Research, VA Ann Arbor Healthcare System, NCRC 016-308E, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA.
Background: Central nervous system (CNS)-active polypharmacy (defined as concurrent exposure to three or more antidepressant, antipsychotic, antiseizure, benzodiazepine, opioid, or nonbenzodiazepine benzodiazepine receptor agonists) is associated with significant potential harms in persons living with dementia (PLWD).We conducted a pilot trial to assess a patient nudge intervention's implementation feasibility and preliminary effectiveness to prompt deprescribing conversations between PLWD experiencing CNS-active polypharmacy and their primary care clinicians ("clinicians").
Methods: We used the electronic health record to identify PLWD prescribed CNS-active polypharmacy in primary care clinics from two health systems.
Palliative care is an important part of health services. The individualized care perceptions are is critical for supporting individuality during care and providing quality nursing care. Individualized care not only has, as well as having foundation of the philosophy of nursing but also, is also related to the nurses' empathic tendencies and professional quality of life of nurses.
View Article and Find Full Text PDFAn autonomous vehicles' test case extraction method: Example of vehicle-to-pedestrian scenarios.
Heliyon
January 2025
Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science), Shanghai, 200063, China.
Testing autonomous vehicles (AVs) in hazardous scenarios is a crucial technical approach to ensure their safety. A key aspect of this process is the generation of hazard scenarios. In general, such scenarios are generated through cluster analysis of traffic accident data.
View Article and Find Full Text PDFPerceptions and emotions in postoperative recovery of patients with perianal diseases.
World J Psychiatry
January 2025
Digestive Physiology and Gastrointestinal Motility Lab, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz 91700, Mexico.
This article examines the complex relationship between disease perception, negative emotions, and their impact on postoperative recovery in patients with perianal diseases. These conditions not only cause physical discomfort, but also carry a significant emotional burden, often exacerbated by social stigma. Psychological factors, including stress, anxiety, and depression, activate neuroendocrine pathways, such as the hypothalamic-pituitary-adrenal axis, disrupting the gut microbiota and leading to dysbiosis.
View Article and Find Full Text PDFThe Life Experiences of Loss and Grieving for Indonesian Wives Who Had Lost Their Husbands Because of a Critical Illness: A Case Study.
Int Med Case Rep J
January 2025
Department of Emergency and Critical Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia.
Background: Grieving is an experience of deep mental suffering. It is a very individual process. Grief over the loss of a spouse can have an impact on both physical and mental health.
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