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| http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005006 | DOI Listing |
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Comparative Venomics of the Cryptic Cone Snail Species and .
Mar Drugs
February 2022
Departamento de Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales (MNCN-CSIC), José Gutiérrez Abascal 2, 28006 Madrid, Spain.
Article Synopsis
- The study compared the venom duct transcriptomes and proteomes of two cryptic cone snail species, identifying shared and unique conotoxin precursor superfamilies.
- It discovered three new putative conotoxin precursor superfamilies and noted significant differences in expression, suggesting adaptation to different diets between the species.
- Machine learning was used to predict 3D structures of selected venom proteins, including those that were differentially expressed, highlighting their potential roles in the snails' venom composition.
Conotoxin Diversity in the Venom Gland Transcriptome of the Magician's Cone, .
Mar Drugs
September 2019
Departamento de Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales (MNCN-CSIC), José Gutiérrez Abascal, 2, 28006 Madrid, Spain.
The transcriptomes of the venom glands of two individuals of the magician's cone, , from Okinawa (Japan) were sequenced, assembled, and annotated. In addition, RNA-seq raw reads available at the SRA database from one additional specimen of from the Philippines were also assembled and annotated. The total numbers of identified conotoxin precursors and hormones per specimen were 118, 112, and 93.
View Article and Find Full Text PDFMAGUS: A Shared Tool for the Genetic Community.
Circ Cardiovasc Qual Outcomes
October 2018
Center for Clinical Management and Research, Ann Arbor VA Medical Center, MI (B.K.N.).
Behavioral aspects of spatial competition between red wood ants (Formica aquilonia) and six mass species of Carabidae were studied in field and laboratory experiments. We showed that red wood ants essentially influence spatial distribution of ground beetles on their common territories. Transplantation experiments suggest that in newly established ants' settlements stronger forms of interrelations arise than in old stable colony.
View Article and Find Full Text PDFDeterminants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA.
J Biol Chem
May 2003
Department of Physiology and Biophysics, Cellular and Molecular Neurobiology Research Group, University of Calgary, Canada.
The Conus magus peptide toxin omega-conotoxin MVIIA is considered an irreversible, specific blocker of N-type calcium channels, and is now in clinical trials as an intrathecal analgesic. Here, we have examined the action of MVIIA on mutant and wild type calcium channels transiently expressed in tsA-201 cells. Although we have shown previously that mutations in a putative external EF-hand motif in the domain IIIS5-H5 region alters block by both omega-conotoxin GVIA and MVIIA (Feng, Z.
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