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| http://dx.doi.org/10.1161/CIRCIMAGING.118.008147 | DOI Listing |
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Tannic acid-modified FK506-loaded nanoparticles targeting lymph nodes for acute heart transplant rejection treatment.
Int J Pharm
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Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 China; Clinical Research Center for Medical Imaging in Hubei Province, Wuhan 430022 China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022 China. Electronic address:
Significant efforts have been made to deliver immunosuppressants-loaded nanoparticles (NPs) to lymph nodes (LNs) to mitigate transplant rejection. However, conventional administration techniques encounter challenges in enhancing the retention of NPs in the LNs. Attributing the strong affinity of tannic acid (TA) molecules to the elastin of LN conduits, we developed a novel formulation of NPs encapsulating Tacrolimus (FK506), and subsequently modified with TA to produce TA-FNP with a final diameter of approximately 86.
View Article and Find Full Text PDFThe Labiomandibular Fold Anatomy for Comprehensive Lower Facial Rejuvenation: A Micro-Computed Tomography Investigation.
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Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No.1, Shuaifuyuan, Dongcheng District, Beijing, China.
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View Article and Find Full Text PDFClinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain.
J Cancer Res Clin Oncol
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Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Purpose: Analysis of autofluorescence holds promise for brain tumor delineation and diagnosis. Therefore, we investigated the potential of a commercial confocal laser scanning endomicroscopy (CLE) system for clinical imaging of brain tumors.
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Effects of Retinol, Natural Pea Peptide and Antioxidant Blend in a Topical Formulation: In Vitro and Clinical Evidence.
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Department of Cell Biology and Physiology, The Neuroscience Center, College of Life Sciences, Brigham Young University, Provo, UT, 84602, USA.
Introduction: Retinol has a long history of treating skin conditions, including photoaging. However, skin irritation with repeated use of retinol is well documented. The present study assessed the effectiveness of a novel topical formulation, referred to as retinol topical formulation (RTF), to improve the quality of skin health.
View Article and Find Full Text PDFScleral Remodeling in Early Recovery from Induced Experimental Myopia.
Curr Eye Res
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School of Optometry and Vision Science, University of Waterloo, Waterloo, Canada.
Purpose: To explore the contribution and impact of fibrous scleral remodeling in the early recovery from lens induced myopia of chicks.
Method: Refractive error, axial length and histopathological studies were performed on chicks subject to myopic influence with -10 D goggles unilaterally on the day of hatching for a period of 14 days, after which the eyes were enucleated and immediately fixed for histopathological assessment. Three groups, myopia (measurements taken directly after 14 days), early recovery from induced myopia (chicks allowed a three-hour recovery period by removing goggles before analysis) and control (no goggles) were evaluated.
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