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Rapid response to Anifrolumab in lupus related joint involvement as assessed by ultrasonography: a case series study.
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Lupus Clinic, Rheumatology, Department of Clinical, Internal, Anesthesiologic and Cardiovascular, Sciences, Sapienza University of Rome, Rome, Italy.
Endothelial Dysfunction and Liver Cirrhosis: Unraveling of a Complex Relationship.
Int J Mol Sci
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Liver Unit, CEMAD-Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, 00168 Rome, Italy.
Endothelial dysfunction (ED) is the in the background of multiple metabolic diseases and a key process in liver disease progression and cirrhosis decompensation. ED affects liver sinusoidal endothelial cells (LSECs) in response to different damaging agents, causing their progressive dedifferentiation, unavoidably associated with an increase in intrahepatic resistance that leads to portal hypertension and hyperdynamic circulation with increased cardiac output and low peripheral artery resistance. These changes are driven by a continuous interplay between different hepatic cell types, invariably leading to increased reactive oxygen species (ROS) formation, increased release of pro-inflammatory cytokines and chemokines, and reduced nitric oxide (NO) bioavailability, with a subsequent loss of proper vascular tone regulation and fibrosis development.
View Article and Find Full Text PDFTesting, Experimental Design, and Numerical Analysis of Nanomechanical Properties in Epoxy Hybrid Systems Reinforced with Carbon Nanotubes and Graphene Nanoparticles.
Polymers (Basel)
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Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.
Hybrid nanocomposites incorporating multiple fillers are gaining significant attention due to their ability to enhance material performance, offering superior properties compared to traditional monophase systems. This study investigates hybrid epoxy-based nanocomposites reinforced with multi-walled carbon nanotubes (MWCNTs) and graphene nanosheets (GNs), introduced at two different weight concentrations of the mixed filler, i.e.
View Article and Find Full Text PDFEarly decrease of T-bet B cells during subcutaneous belimumab predicts response to therapy in systemic lupus erythematosus patients.
Immunol Lett
December 2024
Lupus Clinic, Rheumatology, Dipartimento di Scienze Cliniche Internistiche Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Viale del Policlinico 155 00161 Rome, Italy.
Systemic lupus erythematosus (SLE) is characterized by B cell dysregulation and expansion of atypical B cells that may correlate with disease manifestations and activity. This study investigated the impact of subcutaneous (sc) Belimumab (BLM) on the peripheral B cell compartment and on the functional properties of CD21, T-bet and CD11c atypical B cells, in 21 active SLE patients over a 12-month period. At baseline, active SLE patients displayed reduced unswitched IgM memory B cells and expansion of atypical B cells, compared to healthy donors and to SLE patients in remission.
View Article and Find Full Text PDFProteome Reprogramming and Acquired Stress Tolerance in Potato Cells Exposed to Acute or Stepwise Water Deficit.
Plant Cell Environ
December 2024
Department of Pharmacy, University of Salerno, Fisciano, Italy.
Water deficit negatively impacts crop productivity and quality. Plants face these challenges by adjusting biological processes and molecular functions according to the intensity and duration of the stress. The cultivated potato (Solanum tuberosum) is considered sensitive to water deficit, thus breeding efforts are needed to enhance its resilience.
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