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Sex and race disparities in emergency department patients with chest pain and a detectable or mildly elevated troponin.
Am Heart J Plus
January 2025
Department of Emergency Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Identifying and eliminating health disparities is a public health priority. The goal of this analysis is to determine whether cardiac testing or outcome disparities exist by race or sex in patients with detectable to mildly elevated serum troponin.
Methods: We conducted a secondary analysis of the CMR-IMPACT trial that randomized patients with symptoms suggestive of acute coronary syndrome and a detectable or mildly elevated troponin measure from 4 US hospitals to an early invasive angiography or cardiac MRI strategy.
Evaluation of the Adhesion Strength of Ultrathin Gold Coatings on Substrates of Soda-Lime Glass and Cyclo-Olefin-Polymer by Cross-Cut and Scratch Tests under the Influence of a Thermal Shock Test for Use in Biosensors.
ACS Omega
January 2025
Institute for Micro Integration (IFM), University of Stuttgart, Allmandring 9B, 70569 Stuttgart, Germany.
The current demand for highly sensitive, optical sensors in biodiagnostics has prompted the development of ultrathin metal coatings on a range of substrates. Given the potential attenuation of the signal from a plasmonic sensor for the detection of fluorescent molecules when an adhesion layer between the substrate and coating is employed, this study examines the impact of various factors on the adhesion strength between gold coatings and substrates comprising glass and cyclo-olefin-polymer (COP). The objective is to identify potential configurations for high adhesion strength, thereby eliminating the need for an adhesion layer in the fabrication of optical sensors with gold coatings for diagnostic applications or to utilize a minimal adhesion layer thickness.
View Article and Find Full Text PDFFrom Laggard To Leader: Why Health Care In The United States Is Failing, And How To Fix It.
Health Aff (Millwood)
January 2025
Len M. Nichols, Urban Institute, Washington, D.C.
Health care in the United States is among the most technologically advanced in the world, but it is largely failing to meet the needs of the nation. The US can claim international excellence in important areas of care, such as cancer treatment, and it leads the world in biomedical innovation and building a well-prepared and dedicated clinical workforce. The Affordable Care Act was a major step forward in expanding access to health care in the US.
View Article and Find Full Text PDFAccess improvement in healthcare: a 12-step framework for operational practice.
Front Health Serv
January 2025
Department of Radiation Oncology, Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, United States.
Background: Access improvement is a fundamental component of value-based healthcare as it inherently promotes quality by eliminating chokepoints, redundancies, and inefficiencies which could hinder the provisioning of timely care. The purpose of this review is to present a 12-step framework which offers healthcare organizations a practical, thematic-based foundation for thinking about access improvement.
Methods: This study was designed based on the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement.
Exploring a new paradigm for serum-accessible component rules of natural medicines using machine learning and development and validation of a direct predictive model.
Int J Pharm
January 2025
Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China. Electronic address:
In the field of pharmaceutical research, Lipinski's Rule of Five (RO5) was once widely regarded as the prevailing standard for the development of novel drugs. Despite the fact that an increasing number of recently approved drugs no longer adhere to this rule, it continues to serve as a valuable guiding principle in the field of drug discovery. The present study aims to establish a set of rules specifically for the serum-accessible components of natural medicines.
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