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Misleading Renal Function Evaluation Leading to Severe Methotrexate-Induced Toxicity.
Ther Drug Monit
December 2024
Université Jean Monnet, Médecine Intensive Réanimation G, CHU Saint-Etienne, INSERM, Mines Saint Etienne, Saint-Étienne, France.
Low-dose methotrexate has been proposed as therapy for patients with severely disabling psoriasis and psoriatic arthritis. However, it can be associated with severe toxicity, such as pancytopenia, characterized by anemia (hemoglobin level <13 g/dL in men), thrombocytopenia (platelet count <150 × 109/L), and neutropenia or agranulocytosis (neutrophil count <1.5 × 109/L and 0.
View Article and Find Full Text PDFUnmasking the Unusual: Cryptococcal Pericarditis in a Patient with Liver Failure - a Rare Occurrence.
Am J Case Rep
July 2024
Department of Interventional Pulmonology, TidalHealth Peninsula Regional, Salisbury, MD, USA.
BACKGROUND Cryptococcosis is an invasive fungal infection caused by Cryptococcus species complex. C. neoformans is one of the pathogenic species within the genus.
View Article and Find Full Text PDFNecrotizing pancreatitis, microangiopathic hemolytic anemia and thrombocytopenia following the second dose of Pfizer/BioNTech COVID-19 mRNA vaccine.
Wien Klin Wochenschr
August 2023
Klinik Landstraße, Juchgasse 25, 1030, Wien, Austria.
Implementing vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major asset in slowing down the coronavirus disease 2019 (COVID-19) pandemic. For mRNA vaccines, the main severe adverse events reported in pharmacovigilance systems and post-authorization studies were anaphylaxis and myocarditis. Pancreatitis after Pfizer/BioNTech COVID-19 vaccination has been reported only in 10 patients.
View Article and Find Full Text PDFSevere Acute Systemic Reaction After the First Injections of Ixekizumab.
Cutis
January 2022
Dr. Pappas is from the Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania. Dr. Liaqat is from Kaiser Permanente Medical Group, Santa Clara, California. Dr. Halpern is from the University of Pennsylvania, Philadelphia.
We report the case of a 39-year-old woman who presented with generalized malaise; lymphadenopathy; arthritis; dactylitis; ecchymosis; acute onycholysis; and a red, nonpruritic, nonscaly, mottled rash on the right breast 24 hours after the first injections of ixekizumab for psoriasis and psoriatic arthritis. Ixekizumab is a humanized IgG4 monoclonal antibody that binds to IL-17A. Adverse events of ixeki-zumab include infection, inflammatory bowel disease, candidiasis and tinea infections, severe injection-site reactions, arthralgia, headache, infections, neutropenia, and thrombocytopenia.
View Article and Find Full Text PDFAn Uncommon Incidence of Drug-Induced Immune Hemolytic Anemia Secondary to Ceftriaxone.
Cureus
December 2021
Internal Medicine, Sanford Health, Fargo, USA.
A 69-year-old female with a history of psoriatic arthritis was diagnosed with septic arthritis and started on broad-spectrum antibiotics. She underwent left hip excisional debridement of her prosthetic hip joint which grew group B Streptococcus (). She was switched to IV ceftriaxone 2 g daily and her hemoglobin decreased to 5.
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