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| http://dx.doi.org/10.5664/jcsm.7410 | DOI Listing |
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Autoimmune encephalitis: recovery, residual symptoms and predictors of long-term sequelae.
J Neurol Neurosurg Psychiatry
January 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Background: Data regarding long-term recovery from autoimmune encephalitis (AE) remain limited.
Methods: This retrospective observational study investigated outcomes in 182 patients who met the 2016 criteria for definite AE. Recovery data were available in 172 patients.
MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique.
J Neurol
January 2025
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Objectives: To report myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) epidemiology in two American regions using 2023 diagnostic criteria.
Patients And Methods: We compared age- and sex-adjusted incidence and prevalence of MOGAD per 2023 diagnostic criteria in Olmsted County (Minnesota [USA]) and Martinique (Caribbean [FR]) (01/01/2003-12/31/2018, prevalence day) using Poisson regression. Archived sera in 68-85% were available for MOG-IgG testing by live cell-based assay at Mayo Clinic.
Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.
PLoS Biol
January 2025
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, United States of America.
Worrying about perceived threats is a hallmark of multiple psychological disorders including anxiety. This concern about future events is particularly important when an individual is faced with an approach-avoidance conflict. Potential goals to approach are known to be represented in the dorsal hippocampus during theta cycles.
View Article and Find Full Text PDFInvestigation of Transformation Pathways of Polyfluoroalkyl Substances during Chlorine Disinfection.
Environ Sci Technol
January 2025
Department of Civil and Environmental Engineering, University of Missouri, Columbia, Missouri 65211, United States.
Recent regulations on perfluorinated compounds in drinking water underscore the need for a deeper understanding of the formation of perfluorinated compounds from polyfluoroalkyl substances during chlorine disinfection. Among the compounds investigated in this study, N-(3-(dimethylaminopropan-1-yl)perfluoro-1-hexanesulfonamide (N-AP-FHxSA) underwent rapid transformation during chlorination. Within an hour, it produced quantitative yields of various poly- and per-fluorinated products, including perfluorohexanoic acid (PFHxA).
View Article and Find Full Text PDFMultimodal Fusion Artificial Intelligence Model to Predict Risk for MACE and Myocarditis in Cancer Patients Receiving Immune Checkpoint Inhibitor Therapy.
JACC Adv
January 2025
Department of Radiology, Mayo Clinic, Phoenix, Arizona, USA.
Article Synopsis
- The study focused on developing an AI model to predict myocarditis and cardiovascular issues in cancer patients undergoing immune checkpoint inhibitor therapy, which can improve cancer prognosis but poses cardiovascular risks.
- The researchers reviewed data from 2,258 patients treated between 2011 and 2022, finding that 11.7% experienced serious cardiovascular events related to the therapy.
- The AI model, combining electrocardiogram (ECG) data and patient characteristics, showed strong predictive performance with a 0.72 area under the curve, suggesting it could help identify at-risk patients for better clinical management.
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