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Is re-challenge still an option as salvage therapy in multiple myeloma? The case of REal-life BOrtezomib re-Use as secoND treatment for relapsed patients exposed frontline to bortezomib-based therapies (the REBOUND Study). | LitMetric

AI Article Synopsis

  • Researchers studied 134 patients with multiple myeloma (MM) who had good responses to a treatment with bortezomib and were treated again with it after their cancer relapsed.
  • The results showed that 71% of the patients had a positive response to the re-treatment, with some even reaching complete recovery.
  • Overall, the patients lived for an average of 94 months after their treatment, suggesting that using bortezomib again can be a good option for some patients with MM.

Article Abstract

Therapeutic re-challenge is currently a debated issue in the field of multiple myeloma (MM), given the recent availability of several new drugs and combinations. However, very few specific evidences are available about bortezomib re-use at first relapse. This multicenter, observational, retrospective study enrolled 134 MM patients with significant response after bortezomib-based frontline regimens and who had received a first salvage treatment containing bortezomib at relapse. The overall response rate was 71%, including 40% partial responses, 24% very good partial responses, and 7% complete responses. Re-treatment was well-tolerated, with no significant new or unexpected toxicities observed. The median duration of second progression-free survival (PFS) was 15 months, while median PFS2 was 55 months. With a median follow-up of 56 months, overall survival was 94 months for the entire series, without significant differences between patients undergoing or not undergoing transplant procedures. This real-life survey indicates that re-treatment including bortezomib as a first salvage therapy could be still considered in MM patients achieving durable response after initial exposure to bortezomib.

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Source
http://dx.doi.org/10.1007/s00277-018-3524-1DOI Listing

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