AI Article Synopsis
- The study focused on spinal ganglion neurons during skin wound regeneration complicated by S. aureus infection, observing different types of neuron reactions, including reversible and irreversible changes.
- It was found that small B neurons were more prevalent than large type A neurons throughout the experiment.
- Using platelet-rich plasma after hydroimpulsive treatment significantly aided neuron regeneration and reduced cell damage, while using it alone slowed healing and increased neuron damage compared to natural healing.
Article Abstract
We studied the reactions of spinal ganglion neurons accompanying regeneration of the skin wound complicated by S. aureus sp. infection. The appearance of neuron groups with different morphofunctional changes was noted: reversible dystrophic and compensatory reactions and irreversible degenerative changes. The proportion of small B neurons was higher than the proportion of large type A neurons at all terms of the experiment. Application of plateletrich plasma to the wound after preliminary hydroimpulsive treatment considerably reduced cell destruction and stimulated regenerative effects in neurons starting from day 7 of the experiment. Application of platelet-rich plasma without hydroimpulsive treatment decelerated wound regeneration and increased the number of destructively changed neurons even in comparison with spontaneous wound healing. Close correlations between protein synthesis markers and stages of the wound process and its characteristics were revealed.
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| http://dx.doi.org/10.1007/s10517-018-4270-z | DOI Listing |
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