AI Article Synopsis
- The text discusses a comprehensive strategy that integrates multiple areas of chemistry—synthetic, physical, and analytical—along with high-throughput experimentation and process engineering, aimed at developing a large-scale Suzuki-Miyaura process.
- It emphasizes the importance of setting clear criteria and targets to guide the research and optimization of the process.
- The document details the decision-making process and the methods used to enhance the efficiency and effectiveness of large-scale pharmaceutical manufacturing.
Article Abstract
A multidisciplinary approach covering synthetic, physical, and analytical chemistry, high-throughput experimentation and experimental design, process engineering, and solid-state chemistry is used to develop a large-scale (kilomole) Suzuki-Miyaura process. Working against clear criteria and targets, a full process investigation and optimization package is described highlighting how and why key decisions are made in the development of large-scale pharmaceutical processes.
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| http://dx.doi.org/10.1021/acs.joc.8b02351 | DOI Listing |
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