AI Article Synopsis
- The polyomavirus family has thirteen known human species that can lead to serious diseases in immunocompromised and older individuals.
- Recent research on Dutch blood donors shows that most polyomaviruses have high seroprevalence (60-100%), with some variations based on age.
- Newly discovered polyomaviruses like HPyV12, NJPyV, and LIPyV exhibit low seroprevalence (around 5%), raising questions about their impact on human health.
Article Abstract
The polyomavirus family currently includes thirteen human polyomavirus (HPyV) species. In immunocompromised and elderly persons HPyVs are known to cause disease, such as progressive multifocal leukoencephalopathy (JCPyV), haemorrhagic cystitis and nephropathy (BKPyV), Merkel cell carcinoma (MCPyV), and trichodysplasia spinulosa (TSPyV). Some recently discovered polyomaviruses are of still unknown prevalence and pathogenic potential. Because HPyVs infections persist and might be transferred by blood components to immunocompromised patients, we studied the seroprevalence of fourteen polyomaviruses in adult Dutch blood donors. For most polyomaviruses the observed seroprevalence was high (60-100%), sometimes slightly increasing or decreasing with age. Seroreactivity increased with age for JCPyV, HPyV6 and HPyV7 and decreased for BKPyV and TSPyV. The most recently identified polyomaviruses HPyV12, NJPyV and LIPyV showed low overall seroprevalence (~5%) and low seroreactivity, questioning their human tropism. Altogether, HPyV infections are common in Dutch blood donors, with an average of nine polyomaviruses per subject.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198985 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206273 | PLOS |
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