Objective: To study the basic demographic and disease characteristics of multiple sclerosis (MS) in the Southwest Region of the Kingdom of Saudi Arabia.
Methods: This is a retrospective study on demographics and risk factors of 82 MS cases registered in the Armed Forces Hospital, Khamis Mushayt, and the Aseer Central Hospital, Abha, Kingdom of Saudi Arabia. The study was conducted from April 2017 to April 2018. Data was gathered through interview questionnaires and review of medical records. Frequencies, percentages, means, and standard deviations (SD) were used for descriptive statistics. Chi-square and Fisher exact tests were used to investigate differences between male and female patients at 95% confidence intervals (CI). Differences were considered statistically significant at p<0.05.
Results: Out of the total of 82 patients, 50 were female, yielding a female-to-male ratio of 1.56:1. The mean age at disease diagnosis was 30.50+/-9.29 years. As compared to females, the proportion of male patients in the younger age group at disease diagnosis was significantly higher (78.1%, p=0.003) than that in the older age group. Mean disease duration was 4.07+/-3.65 years. The most common variant of the disease was the remitting-relapsing type (64.6%). Optic symptoms (37.8%) were the most common predominant symptom at diagnosis.
Conclusion: This study provides the baseline information about patients with MS in the Aseer region in the Kingdom of Saudi Arabia, and offers useful insights into male-female differences in the manifestation of this disease. Further prospective studies are needed.
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http://dx.doi.org/10.17712/nsj.2018.4.20180235 | DOI Listing |
Clin Cancer Res
January 2025
Bristol-Myers Squibb (United States), Summit, New Jersey, United States.
Purpose: Orvacabtagene autoleucel (orva-cel; JCARH125), a CAR T-cell therapy targeting B-cell maturation antigen (BCMA), was evaluated in relapsed/refractory multiple myeloma (RRMM) patients in the EVOLVE phase 1/2 study (NCT03430011). We applied a modified piecewise model to characterize orva-cel transgene kinetics and assessed the impact of various covariates on its pharmacokinetics (PK).
Experimental Design: The population PK analysis included 159 patients from the EVOLVE study.
Background: Molnupiravir (MOV) is an orally bioavailable ribonucleoside with antiviral activity against all tested SARS-CoV-2 variants. We describe the demographic, clinical, and treatment characteristics of non-hospitalized Danish patients treated with MOV and their clinical outcomes following MOV initiation.
Method: Among all adults (>18 years) who received MOV between 16 December 2021 and 30 April 2022 in an outpatient setting in Denmark, we summarized their demographic and clinical characteristics at baseline and post-MOV outcomes using descriptive statistics.
Chaos
January 2025
School of Science, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
Humans and predators occupy dominant positions in ecosystems and are generally believed to play a decisive role in maintaining ecosystem stability, particularly in the context of virus transmission. However, this may not always be the case. By establishing some ecosystem virus transmission models that cover both human perspectives and predators, we have drawn the following conclusions: (1) Controlling vaccination activities from the human perspective can potentially lower the transmission rate and improve herd immunity, thereby indirectly protecting unvaccinated risk groups.
View Article and Find Full Text PDFInt Urol Nephrol
January 2025
Department of Nursing, China Medical University, Shenyang, Liaoning, China.
Purpose: To conduct a scoping review of the related research on cognitive frailty (CF) in maintenance hemodialysis (MHD) patients, so as to provide a basis for early diagnosis, treatment and intervention of CF in MHD patients.
Methods: Utilizing a scoping review approach, we searched PubMed, Embase, The Cochrane Library, Web of Science, CINAHL, the China Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and Weipu (VIP) for literature on CF in MHD patients up to October 20, 2024. Two researchers conducted independent screening and data extraction of the literature's fundamental characteristics.
Aging Clin Exp Res
January 2025
Research Laboratory Psychology of Patients, Families, and Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Loneliness, social isolation, and living alone are significant risk factors for mortality, particularly in older adults. This systematic review and meta-analysis aimed to quantify their associations with all-cause and cause-specific mortality in older adults, broadening previous research by including more social factors. Comprehensive searches were conducted in PubMed, APA PsycINFO, and CINAHL until December 31, 2023, following PRISMA 2020 and MOOSE guidelines.
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