[Relation between ICOS signaling and Th9 cell polarization in mice infected with ].

Objective: To detect the expression level of ICOS on Th9 cells in mice infected with , and investigate the relation between ICOS signaling and Th9 cell polarization.

Methods: Twenty-five mice with infection were used as models. IL-9cells in CD4 T cells and ICOS cells in Th9 cells of the mice were detected by flow cytometry 0, 4, 7, 9 weeks and 12 weeks after the infection.

Results: Compared with that 0 week after the infection, the proportion of Th9 cells in CD4 T cells of the mice significantly increased 4, 7, 9, 12 weeks after the infection (all < 0.05), and the proportion of ICOS cells in Th9 cells also markedly improved ( < 0.05).

Conclusions: In infection, the ICOS signaling may have a regulatory effect on Th9 cell polarization.