AI Article Synopsis
- - The study aimed to explore how a single carbon dioxide (CO) treatment affects arterial stiffness by measuring aortic pulse-wave velocity (PWV) and augmentation index (AIXao), which indicate stiffness levels.
- - Measurements were taken from 31 patients before CO treatment and at 1, 4, and 8 hours after to assess changes in arterial stiffness.
- - Results showed that while PWV did not change significantly, AIXao decreased at 1 and 4 hours post-treatment but increased again at 8 hours, suggesting CO treatment may temporarily reduce resistance in blood vessels and activate vasodilation pathways.
Article Abstract
Aim: We aimed to investigate the effects of a single carbon dioxide (CO) treatment on arterial stiffness by monitoring the changes of aortic pulse-wave velocity (PWV) and aortic augmentation index (AIXao), which are indicators of arterial stiffness.
Patients And Methods: PWV and AIXao were measured by an invasively validated oscillometric device. The measurements of stiffness parameters were performed before the CO treatment, and at 1, 4 and 8 h after the first treatment.
Results: Thirty-one patients were included. No significant changes were found in PWV. AIXao decreased significantly 1 h and 4 h after CO treatment compared to baseline values (p=0.034 and p<0.001). AIXao increased 8 h after the CO treatment, but remained significantly lower than baseline AIXao values (p=0.016).
Conclusion: CO treatment is capable of reducing peripheral vascular resistance. We hypothesize that CO is not only a temporal vasodilator but is also capable of activating vasodilation pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365751 | PMC |
| http://dx.doi.org/10.21873/invivo.11414 | DOI Listing |
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