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Sustained fertility from first-wave follicle oocytes that pause their growth.
bioRxiv
August 2024
Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research and Department of Obstetrics, Gynecology and Reproductive Science, UCSF, San Francisco, CA 94143 USA.
Ovulation results from the cyclical recruitment of non-renewing, quiescent oocytes for growth. Therefore, the primordial follicles that are established during development from an oocyte encapsulated by granulosa cells are thought to comprise the lifelong ovarian reserve . However, using oocyte lineage tracing in mice, we observed that a subset of oocytes recruited for growth in the first juvenile wave remain paused for many months before continuing growth, ovulation, fertilization and development into healthy offspring.
View Article and Find Full Text PDFThe epigenetic determinants for systemic juvenile idiopathic arthritis phenotyping and treatment response.
BMC Musculoskelet Disord
August 2024
Department of Pediatrics, Mansoura University Children's Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.
Background: Determining the role of epigenetics in systemic juvenile idiopathic arthritis (SJIA) provides an opportunity to explore previously unrecognized disease pathways and new therapeutic targets.
Aim: We aimed to identify the clinical significance of microRNAs (miRNA-26a, miRNA-223) in SJIA.
Materials And Methods: This cross-sectional study was conducted on a group of children with SJIA attending to pediatric rheumatology clinic, at Mansoura University Children's Hospital (MUCH) from December 2021 to November 2022.
Secondary sexual dimorphism and ontogenetic shifts in habitat use by the lesser guitarfish Zapteryx brevirostris.
J Fish Biol
September 2024
Laboratório de Ecologia da Reprodução e do Recrutamento de Organismos Marinhos, Departamento de Oceanografia Biológica, Instituto Oceanográfico (IO), Universidade de São Paulo (USP), São Paulo, Brazil.
Sexual dimorphisms are generated by divergent processes, such as natural or sexual selection and niche convergence. Males and females of the lesser guitarfish, Zapteryx brevirostris, present morphological differences in their discs, and the relationships with the species biology and ecology were unrecognized. Analysing the morphometry of 201 specimens and the influence of bottom features on the frequencies of 188 specimens among life stages and sexes, we found strong evidence that gonadal maturation leads to dimorphisms on discs, validating a concavity on male pectoral fins as a secondary sexual dimorphism and rejecting the hypothesis that such dimorphisms were related to ecological pressures.
View Article and Find Full Text PDFGrowing up with juvenile vulvar lichen sclerosus: the experiences and care needs of adult women with lichen sclerosus since childhood - a qualitative exploration.
Br J Dermatol
September 2024
Department of Dermatology, Erasmus MC University Medical Center Rotterdam, the Netherlands.
Background: Vulvar lichen sclerosus (VLS) is a chronic remitting condition that affects the genital skin of females of all ages. Although qualitative studies have been conducted that have focused on women with VLS in mid-life or beyond, less is known about the experiences of individuals with VLS from childhood or adolescence onward.
Objectives: To gain an understanding of the experiences of women with a history of juvenile VLS (JVLS) with regard to the impact of the disease on their personal lives, and their experiences and needs regarding care and guidance.
Widespread Production of Polyunsaturated Aldehydes by Benthic Diatoms of the North Pacific Ocean's Salish Sea.
J Chem Ecol
June 2024
Departments of Chemistry and Marine and Coastal Science, Western Washington University, Bellingham, WA, USA.
Diatoms are key primary producers across marine, freshwater, and terrestrial ecosystems. They are responsible for photosynthesis and secondary production that, in part, support complex food webs. Diatoms can produce phytochemicals that have transtrophic ecological effects which increase their competitive fitness.
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