AI Article Synopsis
- Stem cells have various decisions to make, such as cell division, differentiation, apoptosis, or entering a non-dividing state.
- Neural stem cells in the central nervous system exhibit these behaviors at specific times and locations during development.
- The review discusses recent insights into the factors influencing different stem cell-fate decisions, enhancing our understanding of stem cell identity and behavior.
Article Abstract
Stem cells face a diversity of choices throughout their lives. At specific times, they may decide to initiate cell division, terminal differentiation, or apoptosis, or they may enter a quiescent non-proliferative state. Neural stem cells in the central nervous system do all of these, at stereotypical times and anatomical positions during development. Distinct populations of neural stem cells offer a unique system to investigate the regulation of a particular stem cell behavior, while comparisons between populations can lead us to a broader understanding of stem cell identity. is a well-described and genetically tractable model for studying fundamental stem cell behavior and the mechanisms that underlie cell-fate decisions. This review will focus on recent advances in our understanding of the factors that contribute to distinct stem cell-fate decisions within the context of the nervous system.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315890 | PMC |
| http://dx.doi.org/10.3390/jdb6040025 | DOI Listing |
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