AI Article Synopsis
- Domestication significantly influenced modern societies, particularly highlighted by the sequencing of 200 genomes of the chocolate plant, L.
- The Criollo population was domesticated about 3,600 years ago, leading to selective pressures on genes related to anthocyanins, theobromine metabolism, and disease resistance.
- Increased domestication in Criollo plants has resulted in a higher prevalence of harmful mutations, negatively impacting their productivity and leading to reduced bean yields as Criollo ancestry rises.
Article Abstract
Domestication has had a strong impact on the development of modern societies. We sequenced 200 genomes of the chocolate plant L. to show for the first time to our knowledge that a single population, the Criollo population, underwent strong domestication ~3600 years ago (95% CI: 2481-13,806 years ago). We also show that during the process of domestication, there was strong selection for genes involved in the metabolism of the colored protectants anthocyanins and the stimulant theobromine, as well as disease resistance genes. Our analyses show that domesticated populations of (Criollo) maintain a higher proportion of high-frequency deleterious mutations. We also show for the first time the negative consequences of the increased accumulation of deleterious mutations during domestication on the fitness of individuals (significant reduction in kilograms of beans per hectare per year as Criollo ancestry increases, as estimated from a GLM, = 0.000425).
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191438 | PMC |
| http://dx.doi.org/10.1038/s42003-018-0168-6 | DOI Listing |
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