Recruitment of naturally occurring suppressive CD4, CD25, and FOXP3 regulatory T cells (T) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human T express CCR4 and can be recruited to the TME through the C-C chemokines CCL17 and CCL22. We have recently developed a series of potent, orally bioavailable small molecule antagonists of CCR4 that can block recruitment of T into the TME.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187395 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.8b00351 | DOI Listing |
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