AI Article Synopsis
- Conducted an exploratory RNA transcriptome study to identify RNA expression signatures in familial ADHD using blood samples from three cases and their controls.
- Detected 7 differentially expressed transcripts linked to pathways related to Huntington's disease and axonal guidance signaling, both of which have been previously associated with ADHD.
- Results suggest that blood transcriptome analysis could serve as a potential method for identifying ADHD patterns.
Article Abstract
We have carried an exploratory study by blood transcriptome to find RNA expression signatures in familial ADHD. Samples were collected from three cases with familial ADHD and their paired controls and evaluated by RNA-Seq. Transcriptome profiling identified 7 differentially expressed transcripts with a FDR <0.05 that were involved in pathways in Huntington's disease or axonal guidance signaling previously implicated in ADHD, and enriched for signal peptide, growth factor binding, and notably the lipid metabolism pathways. These findings show that blood transcriptome can have an associated signature and highlight a potential to use blood transcriptome to identify patterns of ADHD.
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| http://dx.doi.org/10.1016/j.psychres.2018.10.025 | DOI Listing |
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