Perioperative Esmolol and Opioids: Is More Really Less?

Reg Anesth Pain Med

From the Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, Baltimore, MD.

Published: November 2018

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http://dx.doi.org/10.1097/AAP.0000000000000877DOI Listing

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Article Synopsis
  • A study aimed to compare the effects of intravenous esmolol and lidocaine on the quality of recovery (QoR) in patients undergoing functional endoscopic sinus surgery (FESS).
  • 60 patients were randomly assigned to receive either esmolol or lidocaine infusions, with their recovery assessed using the QoR-15 score and various other parameters.
  • The results showed esmolol was comparable to lidocaine for postoperative recovery quality and offered benefits like better surgical field quality and less fluctuation in patient hemodynamics during surgery.
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Pheochromocytoma (PCC) surgery presents significant challenges due to the hemodynamic instability induced by catecholamine release. Effective perioperative management is essential to minimize complications and ensure optimal outcomes. This comprehensive review examines the role of esmolol, a short-acting beta-blocker, in hemodynamic stabilization during PCC surgery.

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Perioperative effects of different hypotensive anesthesia techniques in orthognathic surgery.

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Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Erciyes University, Kayseri, Turkiye

Background: This study aimed to investigate the effectiveness of combining sevoflurane with remifentanil, esmolol, or nitroglycerin for hypotensive anesthesia and determine the suitable hypotensive anesthesia method for orthognathic surgery.

Material And Methods: This retrospective study included 60 patients who underwent orthognathic surgery for developmental malocclusion. They were divided into three groups based on the hypotensive agent preferences: Group 1 (n = 20), sevoflurane and remifentanil; Group 2 (n = 20), sevoflurane and esmolol; Group 3 (n = 20), sevoflurane and nitroglycerin.

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Landiolol is an ultra-short-acting, selective β1-adrenergic receptor blocker that was originally approved in Japan for the treatment of intraoperative tachyarrhythmias. It has gained attention for its use in the management of tachyarrhythmias and perioperative tachycardia, especially atrial fibrillation for both cardiac and non-cardiac surgeries. It can be the ideal agent for heart rate control due to its high β1-selectivity, potent negative chronotropic effect, a limited negative inotropic potential, and an ultrashort elimination half-life (around 4 min); moreover, it may have a potential therapeutic effects for sepsis and pediatric patients.

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