Background: The hyperglycemic state is known to shorten the erythrocyte life span. Erythrocyte creatine (EC) reflects the mean erythrocyte age and is useful as an indicator of hemolysis. Here, we studied the relationship between EC and glycemic control indicators [HbA1c or glycated albumin (GA)] in non-diabetic subjects and diabetic patients.
Methods: This study included 119 patients with type 2 diabetes mellitus (T2DM) and 76 non-diabetic subjects matched by sex and age. We studied the relationships between EC and HbA1c or GA in patients with T2DM and non-diabetic subjects.
Results: Erythrocyte creatine in T2DM patients was significantly higher than that in non-diabetic subjects, and the ratio of high EC levels (>1.8 μmol/g Hb) in T2DM patients was significantly higher as well. Furthermore, female EC was significantly higher than male EC, and the ratio of high EC levels in females was significantly higher than in the males as well. While male EC had no significant correlation with HbA1c or GA, female EC had significant positive correlations with both. Male EC had no significant difference between T2DM patients and non-diabetic subjects, while the EC in female patients with T2DM was significantly higher than in female non-diabetic subjects.
Conclusions: The significant positive correlations of EC with HbA1c and GA in female patients with T2DM suggested that the mean erythrocyte age decreased in female diabetic patients with poor glycemic control.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818614 | PMC |
| http://dx.doi.org/10.1002/jcla.22681 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Diabetes is known to cause cognitive impairments and synaptic dysfunction. This study investigates the effects of (EO), (CT), Vitamin C, and metformin on cognitive function and synaptic density (SYN) in diabetic rats. This work aims to evaluate the impact of various treatments on spatial learning, memory, and SYN in a diabetic rat model.
View Article and Find Full Text PDFClinical Case Scenarios in the Management of Non-diabetic Chronic Kidney Diseases.
Cureus
December 2024
Nephrology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, IND.
Research conducted in India has shown that there is a high prevalence of non-diabetic kidney disease (NDKD) among Indian patients. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are emerging as potential treatments for preventing the progression of chronic kidney disease to advanced stages, regardless of their anti-diabetic effects. Dapagliflozin, which has been approved by the Central Drugs Standard Control Organization, is the SGLT2i drug class approved for use in both DKD and NDKD patients.
View Article and Find Full Text PDFImpact of sodium-glucose cotransporter inhibitors in acute coronary syndrome patients on endothelial function and atherosclerosis related-biomarkers: ATH-SGLT2i pilot study.
Medicine (Baltimore)
November 2024
Department of Cardiology, Rabta Teaching Hospital, University of Medicine Tunis, Tunis, Tunisia.
Little is known about the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2i) on atherosclerosis. We aimed to determine if a 90-day intake of Dapagliflozin could improve atherosclerosis biomarkers (namely endothelial function assessed by flow-mediated dilatation [FMD] and carotid intima-media thickness [CIMT]) in diabetic and non-diabetic acute coronary syndrome (ACS) patients when initiated in the early in-hospital phase. ATH-SGLT2i was a prospective, single-center, observational trial that included 113 SGLT2i naive patients who were admitted for ACS and who were prescribed Dapagliflozin at a fixed dose of 10 mg during their hospital stay for either type 2 diabetes or for heart failure.
View Article and Find Full Text PDFA Cross-Sectional Study of Non-communicable Disease Risk Factors Among Non-diabetic and Non-hypertensive Population.
Cureus
December 2024
Community Medicine, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, IND.
Introduction: Noncommunicable diseases, especially diabetes and hypertension, have emerged as significant public health challenges. Regular screening, even among healthy individuals, is essential for early diagnosis and prevention of complications.
Methods: This cross-sectional study was conducted in an urban ward of the Sangli-Miraj-Kupwad municipal corporation in Maharashtra, India, and cluster random sampling was used to collect data.
Association of resistin rs1862513, rs10401670 and rs3745367 polymorphisms with resistin level and insulin resistance in an Iranian type 2 diabetic population.
J Diabetes Metab Disord
June 2025
Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Tehran, Iran.
Objectives: The study investigates the association of single nucleotide polymorphisms (SNP) in resistin gene (RETN) with resistin level, insulin resistance, and the risk of type 2 diabetes in an early diagnosed type 2 diabetic population of Iran.
Methods: The total of 80 healthy subjects and 80 individuals diagnosed with type 2 diabetes. To ascertain the genotypes of rs1862513 and rs3745367, we performed the polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP) technique.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!