Bioorg Med Chem Lett
Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, USA.
Published: December 2018
A novel series of pyrazolyltetrahydropyran N-type calcium channel blockers are described. Structural modifications of the series led to potent compounds in both a cell-based fluorescent calcium influx assay and a patch clamp electrophysiology assay. Representative compounds from the series were bioavailable and showed efficacy in the rat CFA and CCI models of inflammatory and neuropathic pain.
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http://dx.doi.org/10.1016/j.bmcl.2018.10.007 | DOI Listing |
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