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| http://dx.doi.org/10.4103/0366-6999.243555 | DOI Listing |
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Dynamic change of polarity in spread through air spaces of pulmonary malignancies.
J Pathol
January 2025
Department of Clinical Bio-resource Research and Development, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Spread through air spaces (STAS) is a histological finding of lung tumours where tumour cells exist within the air space of the lung parenchyma beyond the margin of the main tumour. Although STAS is an important prognostic factor, the pathobiology of STAS remains unclear. Here, we investigated the mechanism of STAS by analysing the relationship between STAS and polarity switching in vivo and in vitro.
View Article and Find Full Text PDFFSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells.
Sci Rep
January 2025
Medical Imaging Center, First Affiliated Hospital, Jiamusi University, Jiamusi, Heilongjiang, China.
Chronic hyperglycemia, a hallmark of diabetes, can trigger inflammatory responses in the kidney, leading to diabetic nephropathy (DN). Follistatin-like protein 1 (FSTL1) has emerged as a potential therapeutic target in various kidney diseases. This study investigated the effect of high glucose on FSTL1 expression and its role in oxidative stress and cellular transdifferentiation injury in HK-2 human proximal tubule epithelial cells, a model of DN.
View Article and Find Full Text PDFPlasma FSTL-1 as a noninvasive diagnostic biomarker for patients with advanced liver fibrosis.
Hepatology
November 2024
Hepatobiliary Center, The First Affiliated Hospital with Nanjing Medical University, Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, China.
Background And Aims: Reliable novel noninvasive biomarkers for the diagnosis of advanced liver fibrosis are urgently needed in clinical practice. We aimed to investigate the accuracy of plasma Follistatin-like protein 1 (FSTL-1) in the diagnosis of advanced liver fibrosis in chronic liver diseases.
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Follistatin like-1 () regulates adipose tissue development in zebrafish.
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Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Obesity is a highly prevalent disorder with complex aetiology. Therefore, studying its associated cellular and molecular pathways may be aided by analysing genetic tractable diseases. In this context, the study of ciliopathies such as Bardet-Biedl syndrome has highlighted the relevance of primary cilia in obesity, both in the central nervous system and peripheral tissues.
View Article and Find Full Text PDFFSTL1 protects against acute aortic dissection by suppressing vascular smooth muscle cell phenotypic switching and degradation of the extracellular matrix.
J Mol Cell Cardiol
January 2025
Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China; Department of Cardiology, Guangdong Provincial Key Laboratory of Arrhythmia and Electrophysiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China. Electronic address:
Article Synopsis
- Acute aortic dissection (AAD) is a serious cardiovascular emergency linked to changes in vascular smooth muscle cells and the breakdown of the extracellular matrix, with Follistatin-like 1 (FSTL1) found to play a protective role in related cardiovascular issues.
- The study showed that FSTL1 levels were significantly lower in both human and mouse AAD models, and adding FSTL1 back helped improve VSMC function and reduce damage in the aorta.
- Mechanistically, the research revealed that FSTL1 can enhance the phosphorylation of AMPK, suggesting that targeting FSTL1 could be a novel approach for preventing and treating AAD.
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