AI Article Synopsis
- IgM-secreting myelomas and lymphomas, such as Waldenström macroglobulinemia, can lead to various kidney issues, including specific types of glomerulonephritis and amyloid deposits.
- The report discusses five unique cases of kidney pathology observed in patients, featuring intracapillary IgM pseudothrombi and changes associated with microangiopathy, alongside intracellular crystals found in two biopsies.
- Two of the patients exhibited low complement levels when they first presented, contributing to the growing body of research on kidney problems tied to paraprotein-related thrombotic microangiopathy.
Article Abstract
IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.
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| http://dx.doi.org/10.1007/s40620-018-0544-9 | DOI Listing |
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