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Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs. | LitMetric

Follicle sinus complexes (FSCs) in muzzle skin as postmortem diagnostic material of rabid dogs.

J Vet Med Sci

Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, 23-35-1, Higashi, Towada, Aomori 034-8628, Japan.

Published: December 2018

AI Article Synopsis

  • Recent research shows that follicle-sinus complexes (FSCs) in dogs' muzzle skin can help diagnose rabies after death.
  • In a study of 226 suspected rabid dogs, researchers found the viral antigen in 211 samples, achieving 100% sensitivity and specificity.
  • The presence of viral RNA and particles was found in Merkel cells, indicating that these cells are targets for the infection and reinforcing the diagnostic value of FSCs for rabies.

Article Abstract

Recently, we reported that follicle-sinus complexes (FSCs) in the muzzle skin are useful for postmortem diagnosis of rabid dogs. Here, we compared the sensitivity and specificity of detecting the viral antigen in the brain and FSCs of 226 suspected rabid dogs, and assessed whether the FSC harbored the virus genome and particles. The viral antigen was detected in 211 of 226 samples with 100% sensitivity and specificity. Viral RNA and particles were observed in the cytoplasm of Merkel cells (MCs). These results suggest that MCs are targets of virus infection and FSCs are useful material for diagnosing rabies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305517PMC
http://dx.doi.org/10.1292/jvms.18-0519DOI Listing

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