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DNA ploidy status as a predictor for malignant transformation in oral leukoplakia: a systematic review and meta-analysis.
Oral Surg Oral Med Oral Pathol Oral Radiol
January 2025
Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, Constituent Unit of KLE Academy of Higher Education and Research, Belgaum, Karnataka India.
Objective: To synthesize literature regarding determination of ploidy status in cases of oral leukoplakia (OL) with the research question: Can DNA ploidy assess malignant transformation (MT) in OL cases?
Study Design: This systematic review was registered in PROSPERO (CRD42022340184). The PECO (Population, Exposure, Comparator, and Outcome) was patients with OL, aneuploidy, diploidy, and MT in OL. Literature search databases included Scopus, PubMed, and Google Scholar.
IGFBP2 Promotes Proliferation and Glycolysis of Endometrial Cancer by Regulating PKM2/HIF-1α Axis.
Cancer Sci
January 2025
Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Endometrial cancer (EC) is a worldwide gynecologic malignancies, with a remarking increase of incidence and mortality rates in recent years. Growing evidence indicates that glucose metabolism reprogramming is the most representative metabolic signature of tumor cells and exploring its modulatory function in EC development will promote identifying potential EC therapeutic targets. IGFBP2 is an insulin-like growth factor binding protein which is closely associated with a variety of metabolic diseases.
View Article and Find Full Text PDFThe Phytochemical Profile of the Petroleum Ether Extract of Leaves and Its Anticancer Effect on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-buta-4 None (NNK)-Induced Lung Cancer in Rats.
Int J Mol Sci
December 2024
Medicinal and Aromatic Plants Research Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
Lung cancer is a prevalent and very aggressive sickness that will likely claim 1.8 million lives by 2022, with an estimated 2.2 million additional cases expected worldwide.
View Article and Find Full Text PDFFingolimod Inhibits C6 Rat Glioma Proliferation and Migration, Induces Sub-G1 Cell Cycle Arrest, Mitochondrial and Extrinsic Apoptosis In Vitro and Reduces Tumour Growth In Vivo.
Clin Exp Pharmacol Physiol
January 2025
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Article Synopsis
- Glioblastoma multiforme (GBM) is a highly aggressive brain tumor that is currently incurable, highlighting the need for new treatment options.
- This study explored the effects of fingolimod, a drug known for its anti-cancer properties, on C6 rat brain cancer cells using various tests to assess cell survival, proliferation, and apoptosis.
- Results showed that fingolimod significantly reduced cell survival and tumor growth in rats, indicating that it may work by inducing cell cycle arrest and apoptosis in GBM cells.
A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma.
Sci Immunol
November 2024
Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
NK cells offer a promising alternative to T cell therapies in cancer. We evaluated IPH6501, a clinical-stage, tetraspecific NK cell engager (NKCE) armed with a non-alpha IL-2 variant (IL-2v), which targets CD20 and was developed for treating B cell non-Hodgkin lymphoma (B-NHL). CD20-NKCE-IL2v boosts NK cell proliferation and cytotoxicity, showing activity against a range of B-NHL cell lines, including those with low CD20 density.
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