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Article Synopsis
- * The assay demonstrated high analytical sensitivity at 50 copies/mL for both clades I and II of MPXV, with clinical sensitivity and specificity rates of 99.21% and 96.64%, respectively.
- * This assay streamlines laboratory processes by integrating nucleic acid extraction and PCR analysis and is crucial for distinguishing between MPXV clades, which is vital for safety in handling potentially regulated samples.
Genomic and transcriptomic analysis of the recent Mpox outbreak.
Vaccine
March 2024
Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy.
Article Synopsis
- * Genomic analysis reveals over 99% sequence identity between recent and historical Mpox cases, indicating a high level of conservation among related viruses, including Cowpox and Variola.
- * Similarities in immune responses were found across different Pox viruses, suggesting that existing Variola vaccines may be effective against Mpox due to these molecular connections.
Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus.
Front Microbiol
May 2022
Section of Biomedical Sciences, Department of Natural and Environmental Sciences, School of Arts and Sciences, American University of Nigeria, Yola, Nigeria.
Article Synopsis
- Orthopoxviruses (OPXVs) can infect both natural hosts and humans, with a recent study focusing on an atypical cowpox virus called CPXV-No-H2, isolated from an 18-year-old in Northern Norway.
- The complete genome of CPXV-No-H2 was sequenced, revealing it has a length of 220,276 base pairs and includes 217 predicted genes, with many genes showing similarities to other OPXVs from the Old World and North America.
- Phylogenetic analysis indicates that CPXV-No-H2 represents a unique clade that might have emerged through multiple recombination events, suggesting the existence of a distinct new group of cowpox viruses related to ECTV-Abatino.
Background: Between 2008 and 2011 about 40 cases of human cowpox were reported from Germany and France. Infections had been acquired via close contact to infected, young pet rats. An identical and unique sequence of the hemagglutinin gene was found in various cowpox virus (CPXV) isolates pointing to a common source of infection.
View Article and Find Full Text PDFGenome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus.
Viruses
May 2018
Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA.
Annotated whole genome sequences of three isolates of the Akhmeta virus (AKMV), a novel species of orthopoxvirus (OPXV), isolated from the Akhmeta and Vani regions of the country Georgia, are presented and discussed. The AKMV genome is similar in genomic content and structure to that of the cowpox virus (CPXV), but a lower sequence identity was found between AKMV and Old World OPXVs than between other known species of Old World OPXVs. Phylogenetic analysis showed that AKMV diverged prior to other Old World OPXV.
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