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p27 overexpression regulates IL-1β in the microenvironment of stem cells and eutopic endometriosis co-cultures.
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Department of Gynecology - Federal University of São Paulo - Escola Paulista de Medicina (UNIFESP-EPM), Rua Mirassol 227, Vila Clementino, São Paulo, SP 04039-002, Brazil; Charitable Association of Blood Collection-COLSAN, Avenida Jandira, 1260 - Indianópolis, São Paulo, SP 04080-006, Brazil.
Endometriosis is a gynecological benign chronic disease defined as the growth of endometrial glands and stroma in extra-uterine sites, most commonly implanted over visceral and peritoneal surfaces within the female pelvis causing inflammatory lesions. It affects around 10% of the female population and is often accompanied by chronic pelvic pain, adhesion formation and infertility. Therefore, endometriosis could be considered a "social disease", since it affects the quality of life, reproductivity and also has a socio-economic impact.
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