Comment on Sjögren et al. (2018) A novel multi-parametric high-content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity in drug discovery. Arch Toxicol 92(10):3175-3190.

Rapid progress is made in the development of high-content screening assays for the prediction of nephrotoxicity. The findings from different laboratories are consistent with respect to endpoints and concentration ranges screened. Discrepancies regarding compound annotation and the predictive performance analysis are discussed.