AI Article Synopsis
- The study found that both lipopolysaccharides (LPS) and porins from gram-negative bacteria can bind to proteins C1q and C1.
- This binding does not require specific antibodies, suggesting an antibody-independent mechanism.
- The interaction between LPS, porins, and C1 is crucial for activating the classical pathway of the complement system, which helps eliminate sensitive bacteria.
Article Abstract
The experiments in this paper provided evidence that, besides lipopolysaccharides (LPS), porins of gram-negative bacteria bind to C1q and C1. From these experiments, we concluded that the association of LPS and porins (outer membrane proteins, OMP) may potentiate the C1q and C1 binding in the absence of specific antibodies. This antibody independent binding of C1 to LPS and porins is a prerequisite for the activation of the classical pathway of complement leading to the killing of serum-sensitive bacteria.
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| http://dx.doi.org/10.1016/0165-2478(87)90102-7 | DOI Listing |
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