The current treatment strategies for osteoporosis (OP) involve promoting osteogenic differentiation and inhibiting adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). According to a theory of traditional Chinese medicine (TCM), the kidneys contain an "essence" that regulate bone metabolism and generate marrow. Kidney disorders are therefore considered to be a major cause of OP as per the principles of TCM, which recommends kidney-tonifying treatments for OP. The Zuogui pill (ZGP) is a classic kidney-tonifying medication that effectively improves OP symptoms. Studies have shown that ZGP can promote the osteogenic differentiation of BMSCs, providing scientific evidence for the TCM theory linking kidneys with bone metabolism. In this review, we have provided an overview of recent studies that examined the underlying mechanisms of ZGP mediated regulation of BMSC osteogenic and adipogenic differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169217 | PMC |
| http://dx.doi.org/10.1155/2018/3717391 | DOI Listing |
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Article Synopsis
- Zuogui Pill (ZGP) is an old Chinese herbal medicine used to help with ovarian aging in women.
- The study looked at how ZGP affects stress in cells and the health of special stem cells in the ovaries of rats that were made old using a drug called cyclophosphamide (CTX).
- Results showed that ZGP made the rats healthier and helped them gain weight and improve their ovary size compared to those affected by CTX.
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