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Heterogeneous appetite patterns in depression: computational modeling of nutritional interoception, reward processing, and decision-making.
Front Hum Neurosci
December 2024
Department of Information Medicine, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Accurate interoceptive processing in decision-making is essential to maintain homeostasis and overall health. Disruptions in this process have been associated with various psychiatric conditions, including depression. Recent studies have focused on nutrient homeostatic dysregulation in depression for effective subtype classification and treatment.
View Article and Find Full Text PDF'Some Days Are Not a Good Day to Be a Mum': Exploring Lived Experiences of Guilt and Shame in the Early Postpartum Period.
Eur J Investig Health Psychol Educ
December 2024
Department of Psychology, Institute of Population Health, University of Liverpool, Liverpool L69 7ZA, UK.
The first 16 weeks postpartum are particularly challenging for a new mother and are associated with an elevated risk of experiencing psychological distress. Guilt and shame have been identified as significant predictors of other forms of psychological distress, such as anxiety and depression. However, guilt and shame are poorly distinguished in pre-existing literature.
View Article and Find Full Text PDFMultidimensional Effects of Stress on Neuronal Exosome Levels and Simultaneous Transcriptomic Profiles.
Biol Psychiatry Glob Open Sci
January 2025
Department of Psychiatry, New York University Grossman School of Medicine, New York, New York.
Background: An excess of exosomes, nanovesicles released from all cells and key regulators of brain plasticity, is an emerging therapeutic target for stress-related mental illnesses. The effects of chronic stress on exosome levels are unknown; even less is known about molecular drivers of exosome levels in the stress response.
Methods: We used our state-of-the-art protocol with 2 complementary strategies to isolate neuronal exosomes from plasma, ventral dentate gyrus, basolateral amygdala, and olfactory bulbs of male mice to determine the effects of chronic restraint stress (CRS) on exosome levels.
Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.
Genome Med
December 2024
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Article Synopsis
- The study explores the biological differences linked to PTSD by examining DNA methylation changes in blood, suggesting they could indicate susceptibility or effects of trauma.
- Conducted by the Psychiatric Genomics Consortium, the research included nearly 5,100 participants to identify specific genetic markers associated with PTSD.
- Results showed 11 significant CpG sites related to PTSD, with some also showing correlations between blood and brain tissue methylation, highlighting their potential role in understanding PTSD biology.
Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database.
Brain Imaging Behav
November 2024
Department of Geriatric Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Article Synopsis
- * This study examined how voxel-mirrored homotopic connectivity (VMHC) from resting-state fMRI can be used as a biomarker to differentiate between mild, moderate, and severe cases of MDD among patients and healthy controls.
- * Results showed significant differences in VMHC in specific brain regions, with patterns correlating to depression severity as measured by the Hamilton Depression Scale, indicating that VMHC may be useful for diagnosing and classifying MDD severity.
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