AI Article Synopsis
- Botulinum toxin A (BoNT-A) is used to treat muscle disorders by blocking acetylcholine release, and the study compares two types, prabotulinumtoxinA (PRA) and onabotulinumtoxinA (ONA), in hypertrophic myostatin-deficient mice.
- Injection of BoNT-A (at various dosages) led to muscle atrophy and reduced hypertrophy in these mice over a 2-month period, assessed through various studies like nerve conduction and imaging.
- Both PRA and ONA effectively regulate muscle size and myofibre characteristics, indicating potential for treating rare muscle hypertrophic diseases, with PRA showing similar local efficacy to ONA.
Article Abstract
Botulinum toxin A (BoNT-A) is used clinically for various muscle disorders and acts by preventing the release of the neurotransmitter acetylcholine into the synapse space. Here, we compared the efficacy of prabotulinumtoxinA (PRA) and onabotulinumtoxinA (ONA) for the reduction in hypertrophy in myostatin-deficient (Mstn ) mice. Two different BoNT-A products (2.5, 10 and 25 U/kg) were injected to paralyse the hindlimb for 2 months, after which sciatic nerve conduction study, 3D micro-CT, haematoxylin and eosin (H&E) and dystrophin staining were conducted. Administration of BoNT-A products induced denervation-mediated atrophy and alleviated muscle hypertrophy generated in Mstn mice. The present study revealed that each BoNT-A regulates skeletal muscle size, myofibre number and myofibre diameter in Mstn mice. The potential applicability of BoNT-A for the treatment of rare muscle hypertrophic diseases was demonstrated. Compared with ONA, PRA had a comparable ability to act in the local area.
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| http://dx.doi.org/10.1111/bcpt.13151 | DOI Listing |
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