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Treatment of familial glomangiomatosis with Nd:YAG laser: a case report.
J Cosmet Laser Ther
August 2024
Department of Dermatology, University Hospital of Toulouse, Toulouse, France.
Article Synopsis
- Familial glomangiomatosis is a rare condition caused by a genetic change that leads to abnormal blood vessel growth, called glomus tumors.
- An 11-year-old girl with this condition was treated successfully using a special laser called Nd:YAG long-pulse laser.
- After three laser treatments, her tumors shrank by more than 80%, her pain disappeared, and there were no side effects.
Loss-of-function variants in GLMN are associated with generalized skin hyperpigmentation with or without glomuvenous malformation.
Br J Dermatol
June 2024
Dermatology Hospital, Southern Medical University, Guangzhou, China.
Background: Inherited hyperpigmented skin disorders comprise a group of entities with considerable clinical and genetic heterogenicity. The genetic basis of a majority of these disorders remains to be elucidated.
Objectives: This study aimed to identify the underlying gene for an unclarified disorder of autosomal-dominant generalized skin hyperpigmentation with or without glomuvenous malformation.
A rapidly growing cutaneous malignant glomus tumor with a CCND3 mutation.
J Cutan Pathol
February 2023
Division of Dermatopathology, Joint Pathology Center, Silver Spring, Maryland, USA.
Glomus tumors are rare mesenchymal neoplasms composed of cells resembling the glomus body. They are most frequently seen in subungual regions but have been reported to arise in almost every anatomic location. Malignant glomus tumors, also called glomangiosarcomas, of cutaneous origin are exceedingly rare with only 47 reported cases.
View Article and Find Full Text PDFTwo cases of familial glomuvenous malformation and description of a novel pathogenic mutation in glomulin gene (GLMN).
Int J Dermatol
February 2023
Department of Dermatology, Pontevedra University Hospital, Pontevedra, Spain.
MET somatic activating mutations are responsible for lymphovenous malformation and can be identified using cell-free DNA next generation sequencing liquid biopsy.
J Vasc Surg Venous Lymphat Disord
May 2021
Medical Genetics, University of Siena, Siena, Italy; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy. Electronic address:
Objective: Germline mutations of either the endothelial cell-specific tyrosine kinase receptor TIE2 or the glomulin (GLMN) gene are responsible for rare inherited venous malformations. Both genes affect the hepatocyte growth factor receptor c-Met, inducing vascular smooth muscle cell migration. Germline mutations of hepatocyte growth factor are responsible for lymphatic malformations, leading to lymphedema.
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