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| http://dx.doi.org/10.2174/1573403X1404181008143841 | DOI Listing |
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Commentary: Handwriting but not typewriting leads to widespread brain connectivity: a high-density EEG study with implications for the classroom.
Front Psychol
January 2025
Aix Marseille Univ, CNRS, CRPN, Marseille, France.
Role of the X Chromosome in Alzheimer Disease Genetics.
JAMA Neurol
October 2024
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.
Importance: The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it makes up 5% of the genome and carries a high proportion of genes expressed in the brain, making it particularly appealing as a potential source of unexplored genetic variation in AD.
Objectives: To perform the first large-scale X chromosome-wide association study (XWAS) of AD.
Design, Setting, And Participants: This was a meta-analysis of genetic association studies in case-control, family-based, population-based, and longitudinal AD-related cohorts from the US Alzheimer's Disease Genetics Consortium, the Alzheimer's Disease Sequencing Project, the UK Biobank, the Finnish health registry, and the US Million Veterans Program.
Lessons from PROMINENT and prospects for pemafibrate.
Cardiovasc Diabetol
July 2024
Department of Medicine - DIMED, University of Padua, Padua, Italy.
The neutral result of the PROMINENT trial has led to questions about the future for pemafibrate. This commentary discusses possible reasons for the lack of benefit observed in the trial. There were, however, indicators suggesting therapeutic potential in microvascular ischaemic complications associated with peripheral artery disease, with subsequent analysis showing reduction in the incidence of lower extremity ischaemic ulceration or gangrene.
View Article and Find Full Text PDFGastric Bypass vs Diet and Cardiovascular Risk Factors: A Nonrandomized Controlled Trial.
JAMA Surg
September 2024
Department of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tønsberg, Norway.
Importance: Roux-en-Y gastric bypass (RYGB) is associated with reduced cardiovascular (CV) risk factors, morbidity, and mortality. Whether these effects are specifically induced by the surgical procedure or the weight loss is unclear.
Objective: To compare 6-week changes in CV risk factors in patients with obesity undergoing matching caloric restriction and weight loss by RYGB or a very low-energy diet (VLED).
Importance: Adolescent severe obesity is usually not effectively treated with traditional lifestyle modification therapy. Meal replacement therapy (MRT) shows short-term efficacy for body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) reduction in adolescents, and financial incentives (FIs) may be an appropriate adjunct intervention to enhance long-term efficacy.
Objective: To evaluate the effect of MRT plus FIs vs MRT alone on BMI, body fat, and cardiometabolic risk factors in adolescents with severe obesity.
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