Modelling Time-Dependent Acquisition of Positional Information.

Methods Mol Biol

McGill University, Ernest Rutherford Physics Building, 3600 rue University, H3A2T8, Montreal, QC, Canada.

Published: July 2019

Theoretical and computational modelling are crucial to understand dynamics of embryonic development. In this tutorial chapter, we describe two models of gene networks performing time-dependent acquisition of positional information under control of a dynamic morphogen: a toy-model of a bistable gene under control of a morphogen, allowing for the numerical computation of a simple Waddington's epigenetic landscape, and a recently published model of gap genes in Tribolium under control of multiple enhancers. We present detailed commented implementations of the models using python and jupyter notebooks.

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http://dx.doi.org/10.1007/978-1-4939-8772-6_16DOI Listing

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