Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors.

Genomics has significantly advanced our knowledge of the biology of brain tumors, and refined our classification over the past 10 years. These advances have relied on the unbiased analysis of large cohorts of brain tumors, where they are clustered in an unbiased manner prior to ascribing clinical and biological features. Indeed, this has resulted in the identification of several layers of heterogeneity not previously appreciated by morphology alone. As such, the classification of unknown samples into known biological subgroups can be performed robustly using either gene expression or DNA methylation profiling.