The giant tyrannosaurids were the apex predators of western North America and Asia during the close of the Cretaceous Period. Although many tyrannosaurid species are known from numerous skeletons representing multiple growth stages, the early evolution of Tyrannosauridae remains poorly known, with the well-known species temporally restricted to the middle Campanian-latest Maastrichtian (∼77-66 Ma). The recent discovery of a new tyrannosaurid, , from the Wahweap Formation of Utah provided new data on early Campanian (∼80 Ma) tyrannosaurids. Nevertheless, the early evolution of Tyrannosauridae is still largely unsampled. We report a new tyrannosaurid represented by an associated skeleton from the lower Campanian Allison Member of the Menefee Formation of New Mexico. Despite fragmentation of much of the axial and appendicular skeleton prior to discovery, the frontals, a metacarpal, and two pedal phalanges are well-preserved. The frontals exhibit an unambiguous autapomorphy and a second potential autapomorphy that distinguish this specimen from all other tyrannosaurids. Therefore, the specimen is made the holotype of the new genus and species . A phylogenetic analysis places in the tyrannosaurid subclade Tyrannosaurinae. Laser-scanning the frontals and creation of a composite 3-D digital model allows the frontal region of the skull roof of to be reconstructed.
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http://dx.doi.org/10.7717/peerj.5749 | DOI Listing |
Protein Pept Lett
December 2024
Department of Chemistry and Biochemistry, Loyola Marymount University, 1 LMU Drive, Los Angeles, CA90045, USA.
Introduction: The progression of type 2 diabetes in humans appears to be linked to the loss of insulin-producing β-cells. One of the major contributors to β-cell loss is the formation of toxic human IAPP amyloid (hIAPP, Islet Amyloid Polypeptide, amylin) in the pancreas. Inhibiting the formation of toxic hIAPP amyloid could slow, if not prevent altogether, the progression of type 2 diabetes.
View Article and Find Full Text PDFSci Transl Med
May 2023
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Although blocking the binding of vascular endothelial growth factor (VEGF) to neuropilin-2 (NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of effective reagents that can be used clinically has hampered this potential therapy. Here, we describe the generation of a fully humanized, high-affinity monoclonal antibody (aNRP2-10) that specifically inhibits the binding of VEGF to NRP2, conferring antitumor activity without causing toxicity. Using triple-negative breast cancer as a model, we demonstrated that aNRP2-10 could be used to isolate cancer stem cells (CSCs) from heterogeneous tumor populations and inhibit CSC function and epithelial-to-mesenchymal transition.
View Article and Find Full Text PDFAnticancer Res
June 2022
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.;
Background/aim: miRNA functional analysis involves transfection with miRNA-based oligos to identify gain-of or loss-of function cellular phenotypes. Apoptosis is a common phenotypic endpoint for miRNA functional analysis. We report that four common cell dissociation enzymes, TrypLE, Accutase, Trypsin, and Accumax, can differentially impact cell viability and apoptosis in Annexin V flow cytometric analysis after miRNA-based transient transfection.
View Article and Find Full Text PDFProtein Pept Lett
December 2021
Department of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, CA 90045, United States.
Aim: To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of human IAPP.
Background: The loss of insulin-producing β-cells and the overall progression of type 2 diabetes appears to be linked to the formation of toxic human IAPP (hIAPP, Islet Amyloid Polypeptide, amylin) amyloid in the pancreas. Inhibiting the initial aggregation of hIAPP has the potential to slow, if not stop entirely, the loss of β-cells and halt the progression of the disease.
PeerJ
April 2021
Zuni Dinosaur Institute for Geosciences, Springerville, Arizona, United States of America.
The neosuchian is known from numerous localities throughout the Campanian of North America, from New Jersey to Montana (USA) and as far south as Coahuila (Mexico). Here we describe six osteoderms, two vertebrae, and a partial tooth discovered in the Menefee Formation of New Mexico and assign them to sp., representing one of the earliest occurrences of this genus on the Laramidian subcontinent, and among the earliest known occurrences of this large alligatoroid in all of North America.
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