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| http://dx.doi.org/10.1165/rcmb.2018-0306ED | DOI Listing |
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Centro de Ecología Integrativa (CEI), Instituto de Ciencias Biológicas, Universidad de Talca, Talca, Chile.
Low temperatures are one of the critical conditions affecting the performance and distribution of plants. Exposure to cooling results in the reprogramming of gene expression, which in turn would be mediated by epigenetic regulation. Antarctica is known as one of the most severe ecosystems, but several climate models predict an increase in average temperature, which may positively impact the development of Antarctic plants; however, under warmer temperatures, plants' vulnerability to damages from low-temperature events increases.
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Am J Epidemiol
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Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Long-term exposure to ambient air pollution has been associated with epigenetic age acceleration (EAA) in adults, but its impact on children remains less understood. This study analyzed data from 457 children (mean age: 7.9 years) in the Project Viva cohort (2007-2010, eastern Massachusetts, USA).
View Article and Find Full Text PDFDifferences in maternal diet fiber content influence patterns of gene expression and chromatin accessibility in fetuses and piglets.
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This study investigates the impact of maternal gestation diets with varying fiber contents on gene expression and chromatin accessibility in fetuses and piglets fed a low fiber diet post weaning. High-fiber maternal diets, enriched with sugar beet pulp or pea internal fiber, were compared to a low-fiber maternal diet to evaluate their effects on liver and muscle tissues. The findings demonstrate that maternal high-fiber diets significantly alter chromatin accessibility, predicted transcription factor activity and transcriptional landscape in both fetuses and piglets.
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Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility factors, immune-mediated tissue injury and environmental influences, most of which appear to act via the gut microbiome. We hypothesized that host-microbe alterations could be used to prognostically stratify patients experiencing relapses up to four years after endoscopy. We therefore examined multiple omics data, including published and new datasets, generated from paired inflamed and non-inflamed mucosal biopsies from 142 patients with IBD (54 CD; 88 UC) and from 34 control (non-diseased) biopsies.
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Noise pollution has become a significant concern for human health, yet its effects on early embryonic development remain underexplored. Specifically, data on the impact of sine wave noise on newly fertilized embryos is limited. This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No.
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