Validation of hybrid angular spectrum acoustic and thermal modelling in phantoms.

Int J Hyperthermia

c Department of Radiology and Imaging Sciences , University of Utah, Salt Lake City , UT, USA.

Published: August 2019

AI Article Synopsis

  • In focused ultrasound (FUS) thermal ablation, a new treatment planning method using hybrid angular spectrum and Pennes' bioheat equation has been validated through experiments on tissue-mimicking phantoms.
  • Simulated temperature profiles showed a mean error of +0.33°C when compared to actual MR thermometry imaging, indicating the simulations are reliable despite some uncertainty.
  • The study highlights the significance of accurately measuring patient-specific tissue properties to enhance treatment planning and outcomes for FUS surgeries.

Article Abstract

In focused ultrasound (FUS) thermal ablation of diseased tissue, acoustic beam and thermal simulations enable treatment planning and optimization. In this study, a treatment-planning methodology that uses the hybrid angular spectrum (HAS) method and the Pennes' bioheat equation (PBHE) is experimentally validated in homogeneous tissue-mimicking phantoms. Simulated three-dimensional temperature profiles are compared to volumetric MR thermometry imaging (MRTI) of FUS sonications in the phantoms, whose acoustic and thermal properties are independently measured. Additionally, Monte Carlo (MC) uncertainty analysis is performed to quantify the effect of tissue property uncertainties on simulation results. The mean error between simulated and experimental spatiotemporal peak temperature rise was +0.33°C (+6.9%). Despite this error, the experimental temperature rise fell within the expected uncertainty of the simulation, as determined by the MC analysis. The average errors of the simulated transverse and longitudinal full width half maximum (FWHM) of the profiles were -1.9% and 7.5%, respectively. A linear regression and local sensitivity analysis revealed that simulated temperature amplitude is more sensitive to uncertainties in simulation inputs than in the profile width and shape. Acoustic power, acoustic attenuation and thermal conductivity had the greatest impact on peak temperature rise uncertainty; thermal conductivity and volumetric heat capacity had the greatest impact on FWHM uncertainty. This study validates that using the HAS and PBHE method can adequately predict temperature profiles from single sonications in homogeneous media. Further, it informs the need to accurately measure or predict patient-specific properties for improved treatment planning of ablative FUS surgeries.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365205PMC
http://dx.doi.org/10.1080/02656736.2018.1513168DOI Listing

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