Crystal structure and synthesis of 3-(1-pyrrol-2-yl)-1-(thio-phen-2-yl)propanone.

Acta Crystallogr E Crystallogr Commun

School of Chemistry, Trinity Biomedical Sciences Institute, 152-160 Pearse Street, Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.

Published: October 2018

The title compound, CHNOS, was obtained in an improved yield compared to previous literature methods. The mol-ecule is essentially planar with a maximum deviation of 0.085 Å from the mean plane through all non-H atoms. There is directive inter-molecular hydrogen bonding in the form of N-H⋯O hydrogen bonds with a distance of 2.889 (3) Å between the pyrrole amine and the ketone carbonyl O atom. The resulting hydrogen-bonding network defines a ribbon parallel to the axis. These ribbons form offset stacks along the axis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176454PMC
http://dx.doi.org/10.1107/S2056989018012331DOI Listing

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