AI Article Synopsis
- T follicular helper (Tfh) cells are a unique type of CD4 T cells that work with B cells to manage immune responses.
- Their differentiation requires interactions with both dendritic cells (DCs) and B cells, and the effectiveness of different DC subsets in priming Tfh cells varies based on the immunization methods used.
- The authors suggest that the location of DC subsets in lymph nodes and their access to antigens are key factors in their ability to support Tfh development, proposing a three-step model for this process.
Article Abstract
T follicular helper (Tfh) cells are a specialized subset of CD4 T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4 effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming. Finally, we provide a three-step model that accounts for the ability of multiple DC subsets and related lineages to support the Tfh differentiation program.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170619 | PMC |
| http://dx.doi.org/10.3389/fimmu.2018.02169 | DOI Listing |
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